Title : Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.

Pub. Date : 2013 Oct 1

PMID : 23975864






1 Functional Relationships(s)
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1 The IFN-gamma-mediated induction of Trim21 was completely abolished by inhibiting protein synthesis with cycloheximide, and Trim21 expression could not be induced by IFN-gamma in Irf1(-/-) cells, demonstrating that IFN-gamma induces Trim21 indirectly via IRF1 and not directly via STAT1 activation. Cycloheximide interferon gamma Homo sapiens