Title : Site-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b.

Pub. Date : 2013 Dec

PMID : 23962003






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. Cysteine interferon beta 1 Homo sapiens
2 Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. Cysteine interferon beta 1 Homo sapiens
3 Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. Cysteine interferon beta 1 Homo sapiens
4 Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. Cysteine interferon beta 1 Homo sapiens