Pub. Date : 2013 Dec
PMID : 23962003
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Covalent modification of IFN-beta with polyethylene glycol (PEG) improves the pharmacokinetic properties of the protein, but can adversely affect the protein"s in vitro bioactivity. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |
| 2 | Covalent modification of IFN-beta with polyethylene glycol (PEG) improves the pharmacokinetic properties of the protein, but can adversely affect the protein"s in vitro bioactivity. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |
| 3 | Random modification of lysine residues in IFN-beta with amine-reactive PEGs decreased the in vitro bioactivity of the protein 50-fold, presumably due to modification of lysine residues near critical receptor binding sites. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |
| 4 | PEGylated IFN-beta proteins that retained high in vitro bioactivity could be obtained by selective modification of the N-terminus of the protein with PEG. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |
| 5 | Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |
| 6 | Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |
| 7 | Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |
| 8 | Here we use site-specific PEGylation technology (targeted attachment of a cysteine-reactive-PEG to an engineered cysteine residue in IFN-beta) to identify several additional amino acid positions where PEG can be attached to IFN-beta without appreciable loss of in vitro bioactivity. | Polyethylene Glycols | interferon beta 1 | Homo sapiens |