Title : Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.

Pub. Date : 2013 Nov

PMID : 23960094






1 Functional Relationships(s)
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1 The major cytotoxic DNA adduct induced by temozolomide and other methylating agents used in malignant glioma and metastasized melanoma therapy is O(6)-methylguanine (O(6)-MeG). O-(6)-methylguanine protein tyrosine phosphatase non-receptor type 4 Homo sapiens