Title : A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.

Pub. Date : 2013 Oct

PMID : 23955302






5 Functional Relationships(s)
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1 These data identify a role for the TSC in responding to ROS at the peroxisome, and identify the peroxisome as a signalling organelle involved in regulation of mTORC1. Reactive Oxygen Species TSC complex subunit 1 Homo sapiens
2 We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). Reactive Oxygen Species TSC complex subunit 1 Homo sapiens
3 We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). Reactive Oxygen Species TSC complex subunit 1 Homo sapiens
4 We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). Reactive Oxygen Species TSC complex subunit 1 Homo sapiens
5 We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). Reactive Oxygen Species TSC complex subunit 1 Homo sapiens