Title : Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation.

Pub. Date : 2013

PMID : 23951242






2 Functional Relationships(s)
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1 In endothelial cells, LIMK-mediated cofilin phosphorylation after thrombin-stimulation of EGFP- or DsRed2-tagged cofilin transfected cells reduced cofilin aggregate formation, whereas inhibition of cofilin phosphorylation after Rho-kinase inhibitor (Y27632) treatment of endothelial cells promoted formation of cofilin aggregates. Y 27632 cofilin 1 Homo sapiens
2 In platelets, cofilin dephosphorylation after thrombin-stimulation and Y27632 treatment led to an increased formation of the cofilin oligomer. Y 27632 cofilin 1 Homo sapiens