Title : Lack of effect of lovastatin therapy on the parameters of whole-body cholesterol metabolism.

Pub. Date : 1990 Sep

PMID : 2394831






1 Functional Relationships(s)
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1 In the new steady state that exists during long-term lovastatin therapy, along with increased expression of the genes for HMG-CoA reductase and the LDL receptor, the body compensates for the effects of the drug so that cholesterol production rate and tissue pool sizes are not changed from pretreatment values. Lovastatin low density lipoprotein receptor Homo sapiens