Title : Toll-like receptor-mediated airway IL-17C enhances epithelial host defense in an autocrine/paracrine manner.

Pub. Date : 2014 Jan

PMID : 23944933






4 Functional Relationships(s)
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1 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens
2 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens
3 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens
4 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens