Pub. Date : 2013
PMID : 23936477
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3"-hydroxycotinine (3HC). | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CYP2A6 mediated nicotine metabolism, and total nicotine clearance, and has been associated with differences in numerous smoking behaviors. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CYP2A6 mediated nicotine metabolism, and total nicotine clearance, and has been associated with differences in numerous smoking behaviors. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CYP2A6 mediated nicotine metabolism, and total nicotine clearance, and has been associated with differences in numerous smoking behaviors. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 5 | This study demonstrates that NMR is not altered by differences in the rate of 3HC glucuronidation, providing further support that NMR is a reliable indicator of CYP2A6 mediated nicotine metabolism. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |