Pub. Date : 2013 Nov
PMID : 23933953
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Compared with placebo, prednisolone 7.5 mg and 30 mg decreased insulin-stimulated capillary recruitment by 9 +- 4% and 17 +- 3%, respectively (p < 0.01). | Prednisolone | insulin | Homo sapiens |
| 2 | In addition, prednisolone 7.5 mg and 30 mg reduced insulin sensitivity (M value) by -11.4 +- 4.5 mumol kg(-1) min(-1) and -25.1 +- 4.1 mumol kg(-1) min(-1) (p < 0.001) and increased postprandial glucose levels by 11 +- 5% and 27 +- 9% (p < 0.001), respectively. | Prednisolone | insulin | Homo sapiens |
| 3 | Prednisolone-induced changes in insulin-stimulated capillary recruitment were associated with insulin sensitivity (r = +0.76; p < 0.001), postprandial glucose concentrations (r = -0.52; p < 0.03) and systolic blood pressure (r = -0.62; p < 0.001). | Prednisolone | insulin | Homo sapiens |
| 4 | Prednisolone-induced changes in insulin-stimulated capillary recruitment were associated with insulin sensitivity (r = +0.76; p < 0.001), postprandial glucose concentrations (r = -0.52; p < 0.03) and systolic blood pressure (r = -0.62; p < 0.001). | Prednisolone | insulin | Homo sapiens |
| 5 | Prednisolone increased resistin concentrations, which were negatively related to insulin-stimulated capillary recruitment (r = -0.40; p = 0.03). | Prednisolone | insulin | Homo sapiens |
| 6 | CONCLUSIONS/INTERPRETATION: Prednisolone-induced impairment of insulin-stimulated capillary recruitment was paralleled by insulin resistance, increased postprandial glucose levels, hypertension and increased circulating resistin concentrations in healthy men. | Prednisolone | insulin | Homo sapiens |