Title : Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.

Pub. Date : 2013 Nov

PMID : 23933835






2 Functional Relationships(s)
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1 METHODS: We compared protein kinase activities and alterations in lipogenic and gluconeogenic enzyme levels during activity of the AMPK activators metformin and AICAR, relative to those of an aPKC-iota inhibitor, in hepatocytes from non-diabetic and type 2 diabetic human organ donors. acadesine protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 RESULTS: Metformin and 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) activated aPKC at concentrations comparable with those required for AMPK activation. acadesine protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens