Title : Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.

Pub. Date : 2013 Aug

PMID : 23930676






1 Functional Relationships(s)
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1 CONCLUSION: The minor alleles of the PPARA rs4253728 and rs4823613 polymorphisms are associated with a better total and LDL-cholesterol-lowering response to simvastatin, possibly through influence on CYP3A4. Simvastatin cytochrome P450 family 3 subfamily A member 4 Homo sapiens