Title : Dopamine-angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease.

Pub. Date : 2013 Sep

PMID : 23925977






3 Functional Relationships(s)
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1 Renin-angiotensin systems are known to act in many tissues, for example, the blood vessel wall or kidney, where a close interaction between angiotensin and dopamine has been demonstrated. Dopamine renin Homo sapiens
2 In animal models, dopamine depletion induces compensatory overactivation of the local renin-angiotensin system, which primes microglial responses and neuron vulnerability by activating NADPH-oxidase. Dopamine renin Homo sapiens
3 In this review we provide evidence suggesting that the renin-angiotensin system may play an important role in dopamine"s mediated neuroinflammation and oxidative stress changes in Parkinson"s disease. Dopamine renin Homo sapiens