Title : The TRPA1 channel and oral hypoglycemic agents: is there complicity in β-cell exhaustion?

Pub. Date : 2013 Nov-Dec

PMID : 23921548






2 Functional Relationships(s)
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1 However, sulfonylureas are ineffective for long-term treatments and ultimately result in the administration of insulin to control glucose levels. Sulfonylurea Compounds insulin Homo sapiens
2 A recent study demonstrating that this drug activates TRPA1, (6) a member of the Transient Receptor Potential (TRP) family of ion channels and a functional protein in insulin secreting cells, (7)(,) (8) has highlighted a possible role for TRPA1 as a potential mediator of sulfonylurea-induced toxicity. Sulfonylurea Compounds insulin Homo sapiens