Title : Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages.

Pub. Date : 2013 Oct 1

PMID : 23921144






2 Functional Relationships(s)
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1 We also observed that PA augmented TLR4 but not TLR2 signal, and the augmentation was mediated by nuclear factor-kappaB (NF-kappaB) pathways. Palmitic Acid toll like receptor 4 Homo sapiens
2 Taken together, this study has demonstrated that PA markedly augments TLR4-mediated proinflammatory signaling triggered by low concentration of LPS in macrophages, and ASMase plays a key role in the augmentation. Palmitic Acid toll like receptor 4 Homo sapiens