Title : Vesicular GABA transporter (VGAT) transports β-alanine.

Pub. Date : 2013 Nov

PMID : 23919636






8 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Vesicular GABA transporter (VGAT) transports beta-alanine. beta-Alanine solute carrier family 32 member 1 Homo sapiens
2 Vesicular GABA transporter (VGAT) transports beta-alanine. beta-Alanine solute carrier family 32 member 1 Homo sapiens
3 In this study, we show that VGAT recognizes beta-alanine as a substrate. beta-Alanine solute carrier family 32 member 1 Homo sapiens
4 Proteoliposomes containing purified VGAT transport beta-alanine using Deltapsi but not DeltapH as a driving force. beta-Alanine solute carrier family 32 member 1 Homo sapiens
5 VGAT also facilitates Cl(-) uptake in the presence of beta-alanine. beta-Alanine solute carrier family 32 member 1 Homo sapiens
6 A previously described VGAT mutant (Glu213Ala) that disrupts GABA and glycine transport similarly abrogates beta-alanine uptake. beta-Alanine solute carrier family 32 member 1 Homo sapiens
7 These findings indicated that VGAT transports beta-alanine through a mechanism similar to those for GABA and glycine, and functions as a vesicular beta-alanine transporter. beta-Alanine solute carrier family 32 member 1 Homo sapiens
8 In the present study, we showed that proteoliposomes containing purified VGAT transport beta-alanine using Deltapsi as a driving force. beta-Alanine solute carrier family 32 member 1 Homo sapiens