Title : Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.

Pub. Date : 2014 May

PMID : 23916961






1 Functional Relationships(s)
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1 RESULTS: GW4064 (5 mumol/L; 24 h), a specific FXR agonist, induced nuclear translocation of the receptor in T84 cells and attenuated Cl(-) secretory responses to both Ca(2+) and cAMP-dependent agonists. GW 4064 nuclear receptor subfamily 1 group H member 4 Homo sapiens