Title : Synergistic effect of combination topotecan and chronomodulated radiation therapy on xenografted human nasopharyngeal carcinoma.

Pub. Date : 2013 Oct 1

PMID : 23906928






3 Functional Relationships(s)
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1 Chronomodulated radiosensitization of TPT was investigated by analysis of tumor regrowth delay (TGD), pimonidazole hydrochloride, histone H2AX phosphorylation, (gamma-H2AX) topoisomerase I (Top I), cell cycle, and apoptosis after treatment with (1) TPT (10 mg/kg) alone; (2) radiation therapy alone (RT); and (3) TPT+RT at 3, 9, 15, and 21 HALO. Topotecan DNA topoisomerase I Homo sapiens
2 Chronomodulated radiosensitization of TPT was investigated by analysis of tumor regrowth delay (TGD), pimonidazole hydrochloride, histone H2AX phosphorylation, (gamma-H2AX) topoisomerase I (Top I), cell cycle, and apoptosis after treatment with (1) TPT (10 mg/kg) alone; (2) radiation therapy alone (RT); and (3) TPT+RT at 3, 9, 15, and 21 HALO. Topotecan DNA topoisomerase I Homo sapiens
3 The expression of Top I in the TPT+RT group was also significantly different from the control tumors at 15 HALO (P<.05). Topotecan DNA topoisomerase I Homo sapiens