Pub. Date : 2013 Oct
PMID : 23902597
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretest 5-HT1A receptor activation by 8-OH-DPAT (0.5 but not 0.1 and 0.02 mg kg(-1) ) caused bradycardia and increased HR variability. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | The 5-HT1A receptor antagonist WAY-100635 (0.03 mg kg(-1) ) blocked these effects of 8-OH-DPAT. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | CONCLUSIONS AND IMPLICATIONS: Pre-training 5-HT1A receptor activation by 8-OH-DPAT (0.5 mg kg(-1) ) impaired memory of conditioned auditory fear based on an attenuated HR increase, whereas pretest administration did not prevent the fear-conditioned HR increase but induced pathological HR dynamics through central ANS dysregulation with cardiac effects similar to acute SSRI overdose. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |