Title : Mitophagy is required for acute cardioprotection by simvastatin.

Pub. Date : 2014 Nov 10

PMID : 23901824






1 Functional Relationships(s)
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1 RESULTS: HL-1 cardiomyocytes exposed to simvastatin for 24 h exhibited diminished protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling, increased activation of unc-51-like kinase 1, and upregulation of autophagy and mitophagy. Simvastatin AKT serine/threonine kinase 1 Homo sapiens