Title : Structural basis for recognition of the third SH3 domain of full-length R85 (R85FL)/ponsin by ataxin-7.

Pub. Date : 2013 Sep 17

PMID : 23892081






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Ataxin-7 (Atx7) is a component of the nuclear transcription co-activator complex; its polyglutamine (polyQ) expansion may cause nuclear accumulation and recruit numerous proteins to the intranuclear inclusion bodies. polyglutamine ataxin 7 Homo sapiens
2 Ataxin-7 (Atx7) is a component of the nuclear transcription co-activator complex; its polyglutamine (polyQ) expansion may cause nuclear accumulation and recruit numerous proteins to the intranuclear inclusion bodies. polyglutamine ataxin 7 Homo sapiens
3 Ataxin-7 (Atx7) is a component of the nuclear transcription co-activator complex; its polyglutamine (polyQ) expansion may cause nuclear accumulation and recruit numerous proteins to the intranuclear inclusion bodies. polyglutamine ataxin 7 Homo sapiens
4 Ataxin-7 (Atx7) is a component of the nuclear transcription co-activator complex; its polyglutamine (polyQ) expansion may cause nuclear accumulation and recruit numerous proteins to the intranuclear inclusion bodies. polyglutamine ataxin 7 Homo sapiens
5 Microscopy imaging demonstrated that sequestration of R85FL by the polyQ-expanded Atx7 in cell is mediated by this specific SH3C-PRR interaction, which is implicated in the pathogenesis of spinocerebellar ataxia 7. polyglutamine ataxin 7 Homo sapiens