Pub. Date : 2013 Oct 1
PMID : 23886862
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 2 | The Na(+) taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 3 | The Na(+) taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 4 | The Na(+) taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 5 | Our current aim was to determine which of the eight cysteine residues of Ntcp is responsible for NO-mediated S-nitrosylation and inhibition of TC uptake. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 6 | Of the eight mutants tested, only C44A Ntcp displayed decreased total and plasma membrane (PM) levels that were also reflected in decreased TC uptake. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 7 | C266A Ntcp showed a decrease in TC uptake that was not explained by a decrease in total expression or PM localization, indicating that C266 is required for optimal uptake. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 8 | We speculated that NO would target C266 since a previous report had shown the thiol reactive compound [2-(trimethylammonium) ethyl] methanethiosulfonate bromide (MTSET) inhibits TC uptake by wild-type NTCP but not by C266A NTCP. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |
| 9 | We speculated that NO would target C266 since a previous report had shown the thiol reactive compound [2-(trimethylammonium) ethyl] methanethiosulfonate bromide (MTSET) inhibits TC uptake by wild-type NTCP but not by C266A NTCP. | Taurocholic Acid | solute carrier family 10 member 1 | Homo sapiens |