Title : Expression of CD1c enhances human invariant NKT cell activation by α-GalCer.

Pub. Date : 2013

PMID : 23885215






2 Functional Relationships(s)
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1 We demonstrate here that CD1c, which is co-expressed with CD1d on blood dendritic cells and on a fraction of B cells, is able to present alpha-galactosylceramide (alpha-GalCer) as a weak agonist to human iNKT cells, and that the presence of CD1c synergistically enhances alpha-GalCerdependent activation of iNKT cells by CD1d. alpha-galactosylceramide CD1c molecule Homo sapiens
2 We demonstrate here that CD1c, which is co-expressed with CD1d on blood dendritic cells and on a fraction of B cells, is able to present alpha-galactosylceramide (alpha-GalCer) as a weak agonist to human iNKT cells, and that the presence of CD1c synergistically enhances alpha-GalCerdependent activation of iNKT cells by CD1d. alpha-galactosylceramide CD1c molecule Homo sapiens