Title : [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].

Pub. Date : 2013 Mar

PMID : 23879997






2 Functional Relationships(s)
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1 When the ERK signaling was blocked by 40 micromol/L PD98059, the 0.001 and 0.01 micromol/L paclitaxel-induced early apoptosis rate in A375 cells was increased by 2.73- and 2.25-fold, respectively. Paclitaxel mitogen-activated protein kinase 1 Homo sapiens
2 Targeting EGFR, ERK and AKT signaling pathways significantly enhances the cytotoxic effect of paclitaxel on human melanoma cells. Paclitaxel mitogen-activated protein kinase 1 Homo sapiens