Title : Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.

Pub. Date : 2013 Sep 12

PMID : 23879431






1 Functional Relationships(s)
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1 While amide- and lactam-based nicotinamide mimetics that inhibit tankyrase activity, such as XAV939, are well-known, herein we report the discovery and evaluation of a novel nicotinamide isostere that demonstrates selectivity over other PARP family members. Niacinamide poly(ADP-ribose) polymerase 1 Homo sapiens