Pub. Date : 2013
PMID : 23874021
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Canakinumab is a human monoclonal antibody that selectively neutralizes IL-1beta, a pro-inflammatory cytokine that plays multiple roles in the atherothrombotic process and that undergoes activation by the NLRP3 inflammasome, a process promoted by cholesterol crystals that in turn leads directly to increased production of IL-1 and IL-6. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |