Title : Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?

Pub. Date : 2013

PMID : 23874021






1 Functional Relationships(s)
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1 Canakinumab is a human monoclonal antibody that selectively neutralizes IL-1beta, a pro-inflammatory cytokine that plays multiple roles in the atherothrombotic process and that undergoes activation by the NLRP3 inflammasome, a process promoted by cholesterol crystals that in turn leads directly to increased production of IL-1 and IL-6. Cholesterol NLR family pyrin domain containing 3 Homo sapiens