Pub. Date : 2013 Sep
PMID : 23867870
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now hypothesize that 5-ASA mediates changes in intestinal epithelial cell (IEC) reactive oxygen species during colitis to affect phosphatase and tensin homolog (PTEN), PI3K, and beta-catenin signaling. | Mesalamine | phosphatase and tensin homolog | Homo sapiens |
| 2 | Data showed 5-ASA-induced peroxisome proliferator-activated receptor gamma DNA binding to the PTEN promoter (chromatin immunoprecipitation) and reduced both phosphorylated and oxidized (inactive) PTEN protein levels. | Mesalamine | phosphatase and tensin homolog | Homo sapiens |
| 3 | Data showed 5-ASA-induced peroxisome proliferator-activated receptor gamma DNA binding to the PTEN promoter (chromatin immunoprecipitation) and reduced both phosphorylated and oxidized (inactive) PTEN protein levels. | Mesalamine | phosphatase and tensin homolog | Homo sapiens |
| 4 | Reduced PI3K/Akt signaling and expression of beta-catenin target genes in 5-ASA-treated CUC patients additionally suggests enhanced PTEN activity as well. | Mesalamine | phosphatase and tensin homolog | Homo sapiens |
| 5 | CONCLUSIONS: Therefore, 5-ASA reduces CUC-induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity, thus attenuating PI3K/Akt signaling. | Mesalamine | phosphatase and tensin homolog | Homo sapiens |