Pub. Date : 2013 Sep
PMID : 23867870
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Analysis of patient samples revealed 5-ASA that also reduced levels of active phosphorylated Akt in inflamed colitis tissue. | Mesalamine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Reduced PI3K/Akt signaling and expression of beta-catenin target genes in 5-ASA-treated CUC patients additionally suggests enhanced PTEN activity as well. | Mesalamine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSIONS: Therefore, 5-ASA reduces CUC-induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity, thus attenuating PI3K/Akt signaling. | Mesalamine | AKT serine/threonine kinase 1 | Homo sapiens |