Pub. Date : 2013 Aug
PMID : 23867624
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The best response was achieved with FK506 (tacrolimus), via a dual mechanism of action as a calcineurin inhibitor that also binds FK-binding protein-12 (FKBP12), a repressor of BMP signaling. | Tacrolimus | FKBP prolyl isomerase 1A | Rattus norvegicus |
| 2 | The best response was achieved with FK506 (tacrolimus), via a dual mechanism of action as a calcineurin inhibitor that also binds FK-binding protein-12 (FKBP12), a repressor of BMP signaling. | Tacrolimus | FKBP prolyl isomerase 1A | Rattus norvegicus |
| 3 | The best response was achieved with FK506 (tacrolimus), via a dual mechanism of action as a calcineurin inhibitor that also binds FK-binding protein-12 (FKBP12), a repressor of BMP signaling. | Tacrolimus | FKBP prolyl isomerase 1A | Rattus norvegicus |
| 4 | The best response was achieved with FK506 (tacrolimus), via a dual mechanism of action as a calcineurin inhibitor that also binds FK-binding protein-12 (FKBP12), a repressor of BMP signaling. | Tacrolimus | FKBP prolyl isomerase 1A | Rattus norvegicus |
| 5 | FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1), ALK2, and ALK3 and activated downstream SMAD1/5 and MAPK signaling and ID1 gene regulation in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin. | Tacrolimus | FKBP prolyl isomerase 1A | Rattus norvegicus |
| 6 | FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1), ALK2, and ALK3 and activated downstream SMAD1/5 and MAPK signaling and ID1 gene regulation in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin. | Tacrolimus | FKBP prolyl isomerase 1A | Rattus norvegicus |