Title : Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma.

Pub. Date : 2013 Jul 18

PMID : 23866964






1 Functional Relationships(s)
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1 RESULTS: Co-treatment of VPA and temsirolimus synergistically inhibited the tumor cell growth and triggered the autophagic cell death, with a significant inhibition of MTOR signaling and MYC oncoprotein. Valproic Acid mechanistic target of rapamycin kinase Homo sapiens