Pub. Date : 2013
PMID : 23861960
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 2 | The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 3 | This supports a deeper link between proteins of the p53-family and metabolic pathways, as PRODH modulates the balance of proline and glutamate levels and those of their derivative alpha-keto-glutarate (alpha-KG) under normal and pathological (tumor) conditions. | Proline | proline dehydrogenase 1 | Homo sapiens |