Title : Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch.

Pub. Date : 2013 Sep

PMID : 23858060






3 Functional Relationships(s)
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1 The DNA-binding transcriptional activator Gal4 and its regulators Gal80 and Gal3 constitute a galactose-responsive switch for the GAL genes of Saccharomyces cerevisiae. Galactose transcriptional regulator GAL3 Saccharomyces cerevisiae S288C
2 Galactose triggers Gal3-Gal80 interaction to rapidly initiate Gal4-mediated transcription activation. Galactose transcriptional regulator GAL3 Saccharomyces cerevisiae S288C
3 Consistent with this, we find that newly discovered nuclear clusters of Gal80 dissipate in response to galactose-triggered Gal3-Gal80 interaction. Galactose transcriptional regulator GAL3 Saccharomyces cerevisiae S288C