Title : The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol.

Pub. Date : 2013 Oct 1

PMID : 23855710






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The chosen oxidizing system was the bicarbonate-dependent peroxidase activity of hSOD1 that consumes H2O2 to produce carbonate radical, which oxidizes the enzyme. carbonate radical superoxide dismutase 1 Homo sapiens
2 MS analyses of turned-over hSOD1 and of a related peptide oxidized by the carbonate radical indicated the formation of a relatively unstable adduct between tempol and hSOD1-Trp32 . carbonate radical superoxide dismutase 1 Homo sapiens