Title : 3-methylcholanthrene induces neurotoxicity in developing neurons derived from human CD34+Thy1+ stem cells by activation of aryl hydrocarbon receptor.

Pub. Date : 2013 Sep

PMID : 23846855






1 Functional Relationships(s)
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1 In concurrence with in silico data, MC exposure significantly up regulates the expression and activity of AHR, CYP1A1 and glutathione S-transferase P1-1 (GSTP1-1) and down regulates the expression of CREB, AMPA and NMDA receptors in hUCBSC-derived neuronal cells at various maturity (0, 2, 4, 8 days of differentiation). Methylcholanthrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens