Title : Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes.

Pub. Date : 2013

PMID : 23840483






2 Functional Relationships(s)
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1 Since heme molecules are essential for the NADPH oxidase maturation and activity, we therefore investigated the consequences of the modulation of Heme oxygenase-1 (HO-1), the limiting enzyme in heme catabolism, on the IL-1beta signaling pathway and more specifically on Nox4 activity. Heme heme oxygenase 1 Homo sapiens
2 Therefore, the downregulation of Nox4 activity by HO-1 induction appeared to be mediated by carbon monoxide (CO) generated from the heme degradation process. Heme heme oxygenase 1 Homo sapiens