Title : Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease.

Pub. Date : 2013 Aug 16

PMID : 23839939






1 Functional Relationships(s)
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1 Surprisingly, HSR activation by HSF1 overexpression or by administration of a small molecule activator lowers the concentration threshold at which HTT forms inclusion bodies in cells expressing aggregation-prone, polyglutamine-expanded fragments of HTT. polyglutamine heat shock transcription factor 1 Homo sapiens