Title : Molecular modeling revealed that ligand dissociation from thyroid hormone receptors is affected by receptor heterodimerization.

Pub. Date : 2013 Jul

PMID : 23831995






1 Functional Relationships(s)
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1 To investigate the effects of heterodimerization, classical molecular dynamics (MD) simulations and random acceleration molecular dynamics (RAMD) simulations were performed to probe the dissociation of triiodothyronine (T3) from a TRalpha-RXR ligand binding domain (LBD) heterodimer and the TRalpha and TRbeta LBDs at the atomic level. Triiodothyronine T cell receptor alpha locus Homo sapiens