Title : Cysteine-mediated aggregation of Au nanoparticles: the development of a H2O2 sensor and oxidase-based biosensors.

Pub. Date : 2013 Aug 27

PMID : 23829431






4 Functional Relationships(s)
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1 As the GOx-biocatalyzed oxidation of glucose yields H2O2, and the AChE/ChOx cascade leads to the formation of H2O2, the two biocatalytic processes could be probed by the cysteine-stimulated aggregation of the Au NPs. Cysteine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. Cysteine acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. Cysteine acetylcholinesterase (Cartwright blood group) Homo sapiens
4 The results suggest the potential implementation of the cysteine-mediated aggregation of Au NPs in the presence of AChE/ChOx as a sensing platform for the optical detection of chemical warfare agents. Cysteine acetylcholinesterase (Cartwright blood group) Homo sapiens