Pub. Date : 2013 Sep
PMID : 23812635
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both the hypoxia-inducible factor (HIF) and phosphatidylinositol 3-kinase (PI3K)/serine/threonine kinase (Akt) pathways have been implicated in hypoxia-induced PASMC proliferation. | pasmc | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, hypoxia-induced increases in cellular proliferation are correlated with increased Trx1 expression, HIF activation, and Akt activation in cultured human PASMC. | pasmc | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | While Trx1 knockdown suppressed hypoxia-induced PI3K-Akt activation in PASMC, PI3K-Akt inhibition prevented hypoxia-induced proliferation but had no effect on hypoxia-induced increases in Trx1 or HIF activation. | pasmc | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Thus, our findings indicate that Trx1 contributes to hypoxia-induced PASMC proliferation by modulating HIF activation and subsequent PI3K-Akt activation. | pasmc | AKT serine/threonine kinase 1 | Homo sapiens |