Title : Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.

Pub. Date : 2013 Dec

PMID : 23808384






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In human lung fibroblasts, the knockdown of LPA2 attenuated the LPA-induced expression of TGF-beta1 and the differentiation of lung fibroblasts to myofibroblasts, resulting in the decreased expression of FN, alpha-SMA, and collagen, as well as decreased activation of extracellular regulated kinase 1/2, Akt, Smad3, and p38 mitogen-activated protein kinase. lysophosphatidic acid transforming growth factor beta 1 Homo sapiens