Title : Effects of repeated allopurinol administration on rat cytochrome P450 activity.

Pub. Date : 2013 May

PMID : 23802435






1 Functional Relationships(s)
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1 Our study showed that allopurinol administration inhibited CYP1A2 activity, causing a significant increase in AUC (0-infinity) (P < 0.01) and t1/2 (P < 0.05) of phenacetin, and a distinct decline in CL (P < 0.01). Phenacetin cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus