Title : Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities.

Pub. Date : 2013 Jul 25

PMID : 23799775






1 Functional Relationships(s)
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1 It was found that bufalin rapidly elicited activation of the ClC-3 Cl(-) channel and subsequently induced apoptosis through inhibition of the PI3K/Akt/mTOR pathway. bufalin AKT serine/threonine kinase 1 Homo sapiens