Pub. Date : 2013 Aug 15
PMID : 23796964
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also establish that increased etoposide-induced multinucleation in HepG2 cells is dependent on the catalytic activity of Akt, as phosphatidylinositol-3-kinase inhibitors as well as the overexpression of kinase-defective Akt reversed this phenotype. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We also establish that increased etoposide-induced multinucleation in HepG2 cells is dependent on the catalytic activity of Akt, as phosphatidylinositol-3-kinase inhibitors as well as the overexpression of kinase-defective Akt reversed this phenotype. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Taken together, these results implicate the Akt/PTEN cellular axis as a major determinant of the etoposide resistance of HCC cells. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |