Pub. Date : 2013 Sep
PMID : 23793290
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potent inhibition of aldehyde dehydrogenase-2 by diphenyleneiodonium: focus on nitroglycerin bioactivation. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 2 | Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN) to yield nitric oxide (NO) or a related species that activates soluble guanylate cyclase (sGC), resulting in cGMP-mediated vasodilation. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 3 | Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN) to yield nitric oxide (NO) or a related species that activates soluble guanylate cyclase (sGC), resulting in cGMP-mediated vasodilation. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 4 | Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN) to yield nitric oxide (NO) or a related species that activates soluble guanylate cyclase (sGC), resulting in cGMP-mediated vasodilation. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 5 | Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN) to yield nitric oxide (NO) or a related species that activates soluble guanylate cyclase (sGC), resulting in cGMP-mediated vasodilation. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 6 | Accordingly, established ALDH2 inhibitors attenuate GTN-induced vasorelaxation in vitro and in vivo. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 7 | However, the ALDH2 hypothesis has not been reconciled with early studies demonstrating potent inhibition of the GTN response by diphenyleneiodonium (DPI), a widely used inhibitor of flavoproteins, in particular NADPH oxidases. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 8 | Our data identify ALDH2 as highly sensitive target of DPI and explain inhibition of GTN-induced relaxation by this drug observed previously. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |