Title : Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates.

Pub. Date : 2013

PMID : 23781297






2 Functional Relationships(s)
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1 Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates. Isothiocyanates NFE2 like bZIP transcription factor 2 Homo sapiens
2 Natural ITCs are key chemopreventive ingredients of cruciferous vegetables, and one of the prime chemopreventive mechanisms of natural isothiocyanates is the induction of Nrf2/ARE-dependent gene expression that plays a critical role in cellular defense against electrophiles and reactive oxygen species. Isothiocyanates NFE2 like bZIP transcription factor 2 Homo sapiens