Pub. Date : 2013 Oct
PMID : 23773341
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 2 | In the present study, we first evaluated the association between COMT rs4680 and the analgesic response to intrathecal morphine in patients with chronic low back pain to provide confirmation of previously reported positive findings. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 3 | In patients with chronic low back pain (n = 74), logistic stepwise regression analysis showed that age (odds ratio [OR]: .90, 95% confidence interval [CI]: .85-.96, P = .002) and the presence of the COMT Met allele (vs Val/Val, OR: .21, 95% CI: .04-.98, P = .048) were predictive factors for lower risk of poor analgesic response to intrathecal morphine. | Morphine | catechol-O-methyltransferase | Homo sapiens |