Pub. Date : 2013 Aug 15
PMID : 23769741
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results showed that simvastatin significantly enhanced proliferation and increased both mRNA and protein levels of cyclin D2, Bcl-2 and the ratio of Bcl-2 to Bax (Bcl-2/Bax). | Simvastatin | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Our results showed that simvastatin significantly enhanced proliferation and increased both mRNA and protein levels of cyclin D2, Bcl-2 and the ratio of Bcl-2 to Bax (Bcl-2/Bax). | Simvastatin | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Our results showed that simvastatin significantly enhanced proliferation and increased both mRNA and protein levels of cyclin D2, Bcl-2 and the ratio of Bcl-2 to Bax (Bcl-2/Bax). | Simvastatin | BCL2 apoptosis regulator | Homo sapiens |
| 4 | Most importantly, treatment with ATP synthase blocker, oligomycin, significantly decreased both simvastatin-stimulated ATP content and cell proliferation, and completely reversed the simvastatin-induced up-regulation of cyclin D2 and Bcl-2 expression in hOBs. | Simvastatin | BCL2 apoptosis regulator | Homo sapiens |
| 5 | Most importantly, treatment with ATP synthase blocker, oligomycin, significantly decreased both simvastatin-stimulated ATP content and cell proliferation, and completely reversed the simvastatin-induced up-regulation of cyclin D2 and Bcl-2 expression in hOBs. | Simvastatin | BCL2 apoptosis regulator | Homo sapiens |
| 6 | These results indicate that the up-regulation of cyclin D2 and Bcl-2/Bax by simvastatin depends on the intact function of ATP synthase in the mitochondria of hOBs. | Simvastatin | BCL2 apoptosis regulator | Homo sapiens |
| 7 | It suggests that simvastatin may promote hOB proliferation, at least partly, via up-regulating mitochondrial function and subsequently cyclin D2 and Bcl-2/Bax expression. | Simvastatin | BCL2 apoptosis regulator | Homo sapiens |