Pub. Date : 2013 Jun
PMID : 23766534
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension. | Chlorides | solute carrier family 26, member 4 | Mus musculus |
| 2 | Here, mice overexpressing the chloride transporter pendrin in intercalated cells of the distal nephron (Tg(B1-hPDS) mice) displayed increased renal absorption of chloride. | Chlorides | solute carrier family 26, member 4 | Mus musculus |
| 3 | Moreover, excessive chloride absorption by pendrin drove parallel absorption of sodium through the epithelial sodium channel ENaC and the sodium-driven chloride/bicarbonate exchanger (Ndcbe), despite an appropriate downregulation of these sodium transporters in response to the expanded vascular volume and hypertension. | Chlorides | solute carrier family 26, member 4 | Mus musculus |