Pub. Date : 2013 Nov
PMID : 23765701
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In cells expressing wt-CFTR, ambroxol increased the Cl(-) conductance, but not the bicarbonate conductance of the CFTR channels. | Ambroxol | CF transmembrane conductance regulator | Homo sapiens |
| 2 | CFBE cells were treated with 100 microM ambroxol for 2, 4 or 8 h. mRNA expression for CFTR and ENaC subunits was analysed by real-time polymerase chain reaction (RT-PCR); protein expression was measured by Western blot. | Ambroxol | CF transmembrane conductance regulator | Homo sapiens |
| 3 | Ambroxol significantly stimulated Cl(-) efflux from CFBE cells (a sixfold increase after 8 h treatment), and enhanced the expression of the mRNA of CFTR and alpha-ENaC, and of the CFTR protein. | Ambroxol | CF transmembrane conductance regulator | Homo sapiens |
| 4 | Ambroxol significantly stimulated Cl(-) efflux from CFBE cells (a sixfold increase after 8 h treatment), and enhanced the expression of the mRNA of CFTR and alpha-ENaC, and of the CFTR protein. | Ambroxol | CF transmembrane conductance regulator | Homo sapiens |
| 5 | Upregulation of CFTR and enhanced Cl(-) efflux after ambroxol treatment should promote transepithelial ion and water transport, which may improve hydration of the mucus, and therefore be beneficial to CF-patients. | Ambroxol | CF transmembrane conductance regulator | Homo sapiens |